Anavar — oxandrolone
Oxandrolone is an oral anabolic steroid derived from dihydrotestosterone. It was designed to have a very strong separation of anabolic and androgenic effect, and no significant estrogenic or progestational activity. Oxandrolone is noted for being quite mild as far as oral steroids are concerned, well tailored for the promotion of strength and quality muscle tissue gains without significant side effects. Milligram for milligram it displays as much as six times the anabolic activity of testosterone in assays, with significantly less androgenicity. This drug is a favorite of dieting bodybuilders and competitive athletes in speed/anaerobic performance sports, where its tendency for pure tissue gain (without fat or water retention) fits well with the desired goals.
|Brand name||Oxandrolone, Lonavar, Lipidex, Antitriol, Anatrophill, Protivar, Oxandrin, Xtendrol, Oxanabolic, Vasorome|
Oxandrolone was first described in 1962. It was developed into a medicine several years later by pharmaceutical giant G.D. Searle & Co. (now Pfizer), which sold it in the United States and the Netherlands under the Anavar trade name. Searle also sold/licensed the drug under different trade names including Lonavar (Argentina, Australia), Lipidex (Brazil), Antitriol (Spain), Anatrophill (France), and Protivar. Oxandrolone was designed to be an extremely mild oral anabolic, one that could even be used safely by women and children. In this regard Searle seems to have succeeded, as Anavar has shown a high degree of therapeutic success and tolerability in men, women, and children alike. During its early years, Anavar had been offered for a number of therapeutic applications, including the promotion of lean tissue growth during catabolic illness, the promotion of lean tissue growth following surgery, trauma, infection, or prolonged corticosteroid administration, or the support of bone density in patients with osteoporosis.
By the 1980’s, the FDA had slightly refined the approved applications of oxandrolone to include the promotion of weight gain following surgery, chronic infection, trauma, or weight loss without definite pathophysiologic reason. In spite of its ongoing track record of safety, Searle decided to voluntarily discontinue the sale of Anavar on July 1, 1989. Lagging sales and growing public concern about the athletic use of anabolic steroids appeared to be at the root of this decision. With the Anavar brand off the market, oxandrolone had completely vanished from U.S. pharmacies. Soon after, oxandrolone products in international markets (often sold by or under license from Searle) began to disappear as well, as the leading global manufacturer of the drug continued its withdrawal from the anabolic steroid business. For several years during the early 1990’s, it looked as if Anavar might be on its way out of commerce for good.
It would be approximately six years before oxandrolone tablets would be back on the U.S. market. The product returned to pharmacy shelves in December 1995, this time under the Oxandrin name by Bio-Technology General Corp. (BTG). BTG would continue selling it for the FDA approved uses involving lean mass preservation, but had also been granted orphandrug status for the treatment of AIDS wasting, alcoholic hepatitis, Turner’s syndrome in girls, and constitutional delay of growth and puberty in boys. Orphan drug status gave BTG a 7- year monopoly on the drug for these new uses, allowing them to protect a very high selling price. Many patients were outraged to learn that the drug would cost them (at wholesale price) between $3.75 and $30 per day, which was many times more costly than Anavar had been just several years back. The release of a 10 mg tablet from BTG several years later did little to reduce the relative cost of the drug.
Oxandrin continues to be sold in the U.S., but is now under the Savient label (formerly known as BTG). It is currently approved by the FDA for “adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis.” Generic versions of the drug are now available in the U.S., which has reduced the price of oxandrolone therapy. Outside of the U.S., oxandrolone remains available, although not widely.
How is Oxandrolone Supplied
Oxandrolone is available in select human drug markets. Composition and dosage may vary by country and manufacturer. The original Anavar brand contained 2.5 mg of steroid per tablet. Oxandrin contains 2.5 mg or 10 mg per tablet. Other modern brands commonly contain 2.5 mg, 5 mg, or 10 mg of steroid per tablet.
Structural Characteristics of Oxandrolone
Oxandrolone is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha to protect the hormone during oral administration and 2) the substitution of carbon-2 in the A-ring with an oxygen atom. Oxandrolone is the only commercially available steroid with such a substitution to its basic ring structure, an alteration that considerably increases the anabolic strength of the steroid (partly by making it resistant to metabolism by 3-hydroxysteroid dehydrogenase in skeletal muscle tissue).
Oxandrolone Side Effects (Estrogenic)
Oxandrolone is not aromatized by the body, and is not measurably estrogenic. Oxandrolone also offers no related progestational activity. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, oxandrolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. Oxandrolone is also very popular among athletes in strength/speed sports such as sprinting, swimming, and gymnastics. In such disciplines one usually does not want to carry around excess water weight, and may find the raw muscle-growth brought about by oxandrolone to be quite favorable over the lower quality mass gains of aromatizable agents.
Oxandrolone Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Oxandrolone is a steroid with low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone.
The low androgenic activity of oxandrolone is due in part to it being a derivative of dihydrotestosterone. This creates a less androgenic steroid because the agent lacks the capacity to interact with the 5-alpha reductase enzyme and convert to a more potent “dihydro” form. This is unlike testosterone, which is several times more active in androgen responsive target tissues such as the scalp, skin, and prostate (where 5-alpha reductase is present in high amounts) due to its conversion to DHT. In essence, oxandrolone has a more balanced level of potency between muscle and androgenic target tissues. This is a similar situation as is noted with Primobolan). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain) might be to add in 200-400 mg of a low estrogenic compound like Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone undecylenate).
Oxandrolone Side Effects (Hepatotoxicity)
Oxandrolone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain.
Oxandrolone appears to offer less hepatic stress than other c-17 alpha alkylated steroids. The manufacturer identifies oxandrolone as a steroid that is not extensively metabolized by the liver like other 17-alpha alkylated orals, which may be a factor in its reduced hepatotoxicity. This is evidenced by the fact that more than a third of the compound is still intact when excreted in the urine. Another study comparing the effects of oxandrolone to other alkylated agents including methyltestosterone, norethandrolone, fluoxymesterone, and methandriol demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention of the agents tested. 20 mg of oxandrolone produced 72% less BSP retention than an equal dosage of fluoxymesterone,which is a considerable difference being that they are both 17-alpha alkylated.
A more recent study looked at escalating doses (20 mg, 40 mg, and 80 mg) of oxandrolone in 262 HIV+ men.The drug was administered for a period of 12 weeks. The group taking 20 mg of oxandrolone per day showed no statistically significant trends of hepatotoxicity in liver enzyme (AST/ALT; amino-transferase and alanine amino-transferase) values. Those men taking 40 mg noticed a mean increase of approximately 30-50% in liver enzyme values, while the group of men taking 80 mg noticed an approximate 50-100% increase. Approximately 10-11% of the patients in the 40 mg group noticed World Health Organization grade III and IV toxicity according to AST and ALT values. This figure jumped to 15% in the 80 mg group. While serious hepatotoxicity cannot be excluded with oxandrolone, these studies do suggest that it is measurably safer than other alkylated agents.
The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.
Oxandrolone Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Oxandrolone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown, non-aromatizable nature, and route of administration. In the previously cited study in HIV+ males, 20 mg of oxandrolone daily for 12 weeks caused a mean serum HDL reduction of 30%. HDL values were suppressed 33% in the 40 mg group, and 50% in the 80 mg group. This was accompanied by a statistically significant increase in LDL values (approximately 30-33%) in the 40 mg and 80 mg groups, further increasing atherogenic risk. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
At one time oxandrolone was looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which was thought to signify potential for this drug as a lipid-lowering agent. With further investigation it was found, however, that any lowering of total cholesterol values was accompanied by a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol that favored greater atherogenic risk. This negates any positive effect this drug might have on triglycerides or total cholesterol, and actually makes it a potential danger in terms of cardiac risk, especially when taken for prolonged periods of time. Today we understand that as a group, anabolic/androgenic steroids tend to produce unfavorable changes in lipid profiles, and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is even more risky to use in this regard than an esterified injectable such as a testosterone or nandrolone.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Oxandrolone Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Oxandrolone is no exception. In the above-cited study on HIV+ males, twelve weeks of 20 mg or 40 mg per day caused an approximate 45% reduction in serum testosterone levels. The group taking 80 mg noticed a 66% decrease in testosterone. Similar trends of decrease were noticed in LH production, with the 20 mg and 40 mg doses causing a 25-30% reduction, and the 80 mg group noticing a decline of more than 50%. Additionally, studies on boys with constitutionally delayed puberty have demonstrated significant suppression of endogenous LH and testosterone with as little as 2.5 mg per day. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Oxandrolone Administration (General)
Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, this steroid should be taken on an empty stomach.
Oxandrolone Administration (Men)
The original prescribing guidelines for Anavar called for a daily dosage of between 2.5 mg and 20 mg per day (5-10 mg being most common). This was usually recommended for a period of two to four weeks, but occasionally it was taken for as long as three months. The dosing guidelines recommended with the current U.S. production form of the drug (Oxandrin, Savient Pharmaceuticals) also call for between 2.5 and 20 mg of drug per day, taken in intermittent cycles of 2 to 4 weeks. The usual dosage for physique- or performanceenhancing purposes is in the range of 15-25 mg per day, taken for 6 to 8 weeks. These protocols are not far removed from those of normal therapeutic situations.
Oxandrolone is often combined with other steroids for a more dramatic result. For example, while bulking one might opt to add in 200-400 mg of a testosterone ester (cypionate, enanthate, or propionate) per week. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention than if taking a higher dose of testosterone alone. For dieting phases, one might alternately combine oxandrolone with a non-aromatizing steroid such as 150 mg per week of a trenbolone ester or 200-300 mg of Primobolan (methenolone enanthate). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain) might be to add in 200-400 mg of a low estrogenic compound like Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone undecylenate).
Oxandrolone Administration (Women)
The original prescribing guidelines for Anavar did not offer separate dosing recommendations for women, although it was indicated that women who were pregnant, or may become pregnant, should not use the drug. The current guidelines for Oxandrin also do not make special dosing recommendations for women. Women who fear the masculinizing effects of many steroids would be quite comfortable using this drug, as these properties are very rarely seen with low doses. For physique- or performance-enhancing purposes, a daily dosage of 5-10 mg should illicit considerable growth without the noticeable androgenic side effects of other drugs. This would be taken for no longer than 4-6 weeks. Eager females may wish to add another mild anabolic such as Winstrol, Primobolan or Durabolin. When combined with such anabolics, the user should notice faster, more pronounced muscle-building effects, but it may also increase the likelihood of seeing androgenic side effects (or hepatotoxicity in the case of Winstrol).
Pharmaceutical preparations containing oxandrolone are fairly limited. The drug is unavailable in Europe, and with a handful of exceptions in the west, its production is increasingly being shifted to less regulated markets in Asia. In reviewing some of the remaining products and changes on the global pharmaceutical market, we have made the following observations.
Various forms of generic oxandrolone are now available in the U.S. in both 2.5 mg and 10 mg dosages, from manufacturers such as Par Pharm, Sandoz, Upsher Smith, and Watson.
Brand name Oxandrin is still available in the U.S. under the Savient brand name. It comes in bottles of 60 (10 mg) tablets or 100 (2.5 mg) tablets each.
Dragon Pharma Anavar, it is prepared in 10 mg and 50 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
The generic Italian product Oxandrolone (SPA) is no longer available. It was previously being made for export sales only. There are no remaining oxandrolone products available on the Italian market.
British Dragon Pharma (Europe) makes the product Oxanabol. It is prepared in 10 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
Atlantis (Mexico) produces an oxandrolone product called Xtendrol. It carries 2.5 mg of steroid per tablet, and comes in a box of 30 tablets each.
Kalpa Pharmaceuticals (India) produces an oxandrolone product called Oxandroxyl. It is prepared in 10 mg and 20 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
Asia Pharma makes the product Oxanabolic in Malaysia. It comes in strips of 10 tablets each, 10 strips per box. Each product should carry a unique product ID code that can be verified with the company for authenticity. This product is presently export only, but the manufacturer claims to be in the process of seeking Thai FDA approval.
Axiolabs (Europe) makes the product Oxandroplex. It is prepared in 10 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
Balkan Pharmaceuticals (Moldova) makes the product Oxandrolon. It is prepared in 10 mg tablets, with 20 tablets contained in each foil and plastic strip.
Sciroxx (Europe) produces an oxandrolone product called Oxanodex. It is prepared in 10 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
Oxandrolone is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
7Lab Pharm (Switzerland) makes the product Oxano-lab. It is prepared in 10 mg and 20 mg tablets, with 100 tablets contained in a sachet. It is widely distributed online.
Magnus Pharmaceuticals makes the product Oxandrolone primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
Oxandrolone was often refereed to as an all purpose oral AAS. This drug was once marketed under the product name (still commonly used trade name) of Anavar. It has the unique quality of significantly stimulating (more than other AAS) the synthesis of phosphocreatine in muscle cells which in turn provides faster regeneration of, and a distinct elevation in, ATP. Of course all AAS have this effect to some extent. Oxandrolone is simply unmatched in this aspect.
(See Creatine for more info) Due to this quality, a rapid build- up in strength was frequently reported and an obvious distinct hardness in muscle was obtained with little weight gain and no aromatization.
Though it is a common belief that Oxandrolone is not very anabolic, a clinical study showed a 44% increase in muscle cell protein synthesis after only 5 days of administration. Since Oxandrolone does not aromatize to estrogen, water retention is reported as quite low and gyno was of no concern. Also, for the same reason, during dieting phases fat deposits were said to be “burned away” more quickly. (Especially when the drug was co-administered with Clenbuterol).
Oxandrolone was reported to stack well with so -called mass steroids such as testosterone or with high anabolic/moderate androgenic steroids such as Equipoise or Nandrolones. Persons over 40 have reported excellent results by stacking 15-25 mg of Oxandrolone daily with 200-400 mg of Deca.
A very hard pre-contest appearance has been achieved by males when stacked with Oxandrolone and Halotestin if a estrogen/progesterone receptor antagonist (*See Nolvadex) had been utilized as well. As I said: “all purpose” was commonly the term of choice.
The drug Oxandrolone was originally manufactured to be used by women to prevent osteoporosis and for children as a cure for stunted growth. The low androgenic quality prevents almost all virilization for women in dosages of 15-mg daily or less. And for the same reason does not cause closure of the epiphysial plates prematurely. An interesting note: Oxandrolone does not suppress any part of the HYPOTHALAMUS-PITUITARY-TESTES AXIS (HPTA). This means Oxandrolone by itself will not significantly suppress natural testosterone production. Therefore it was not uncommon for some athletes to report post-cycle HPTA regeneration protocols that included this drug. The result was prominent lean mass retention.
Anabolic Steroid Guide reference
Searle Company introduced the substance oxandrolone to the U.S. market in 1964 under the name Anavar and it enjoyed great popularity for over two decades until, on July 1, 1989, the production of Anavar was phased out. Today Anavar is manufactured under its various generic names in only a few countries (see above). The compound with the generic name Oxandrolone SPA by S.p.A. Milano Company (Società Prodotti Antibiotici) from Italy is the only original anabolic steroid available in Europe which contains the substance oxandrolone. There are 30 tablets in one box with two push-through strips of 15 tablets each. Oxandrolone is a weak steroid with only a slight androgenic component. It has been shown that Oxandrolone, when taken in reasonable dosages, rarely has any side effects. This is appreciated since Oxandrolone was developed mostly for women and children. Oxandrolone is one of the few steroids which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason Oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Oxandrolone a favored remedy for female athletes since, at a daily dose of 10-15 mg, masculinizing symptoms are observed only rarely.
Bodybuilders and powerlifters, in particular, like Oxandrolone for three reasons. First, Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing liquid (water) in the joints and the muscles. Powerlifters and weightlifters who do not want to end up in a higher weight class take advantage of this since it allows them to get stronger without gaining body weight at the same time. The combination of Oxandrolone and 20 – 30 mg Holotestin daily has proven to be very effective since the muscles also look harder. Similarly good results can be achieved by a simultaneous intake of Oxandrolone and 120-140 mcg Clenbuterol per day. Although Oxandrolone itself does not cause a noticeable muscle growth it can clearly improve the muscle-developing effect of many steroids. Deca-Durabolin, Dianabol, and the various testosterone compounds, in particular, combine well with Oxandrolone to achieve a “mass buildup” because the strength gain caused by the intake of these highly tissue-developing and liquidretaining substances results in an additional muscle mass. A stack of 200 mg Deca-Durabolin/week, 500 mg Testosterone enanthate (e.g. Testoviron Depot 250)/week, and 25 mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca-Durabolin has a distinct anabolic effect and stimulates the synthesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis; and Testosterone enanthate increases the aggressiveness for the workout and accelerates regeneration.
The second reason why Oxandrolone is so popular is that this compound does not aromatize in any dosage. As already mentioned, a certain part of the testosterone present in the body is converted into estrogen. This aromatization process, depending on the predisposition, can vary distinctly from one athlete to another. Oxandrolone is one of the few steroids which cannot aromatize to estrogen. This characteristic has various advantages for the athlete. With Oxandrolone the muscle system does not get the typical watery appearance as with many steroids, thus making it very interesting during the preparation for a competition. In this phase it is especially important to keep the estrogen level as low as possible since estrogen programs the body to store water even if the diet is calorie-reduced. In combination with a diet, Oxandrolone helps to make the muscles hard and ripped. Although Oxandrolone itself does not break downfat, it plays an indirect role in this process because the substance often suppresses the athlete’s appetite. Oxandrolone can also cause some bloating which in several athletes results in nausea and vomiting when the tablets are taken with meals. The package insert of the Italian Oxandrolone notes its effect on the activity of the gastrointestinal tract. Some athletes thus report continued diarrhea. Although these symptoms are not very pleasant they still help the athlete break down fat and become harder. Those who work out for a competition or are interested in gaining quality muscles should combine Oxandrolone with steroids such as Winstrol, Parabolan, Masteron, Primobolan, and Testosterone propionate. A stack of 50 mg Winstrol every two days, 50 mg Testosterone propionate every two days, and 25 mg Oxandrolone every day has proven effective. Another advantage of Oxandrolone’s non-aromatization is that athletes who suffer from high blood pressure or develop gynecomastia of the thymus glands when taking stronger androgenic steroids will not have these side effects with this compound. The. Oxandrolone/Deca-Durabolin stack is a welcome alternative for this group of athletes or for athletes showing signs of poor health during mass buildup with testosterone, Dianabol, or Anadrol 50. Athletes over forty should predomi-nantly use Oxandrolone.
The third reason which speaks well for an intake of Oxandrolone is that even in a very high dosage this compound does not influence the body’s own testosterone production. To make this clear: Oxandrolone does not suppress the body’s own hormone production. The reason is that it does not have a negative feedback mechanism on the hypothalamohypophysial testicular axis, meaning that during the intake of Oxandrolone, unlike during the intake of most anabolic steroids, the testes signal the hypothalamus not to reduce or to stop the release of GnRH (gonadotropin releasing hormone) and LHRH Luteinizing hormon releasing hormone). This special feature of Oxandrolone can be explained by the fact that the substance is not converted into estrogen Oxandrolone (Anavar), when given to normal men in high doses does not reduce the seminal volume or count, nor can it be converted (aromatized) into estrogen.
Oxandrolone combines very well with Andriol, since Andriol does not aromatize in a dosage of up to 240 mg daily and has only slight influence on the hormone production. The daily intake of 280 mg Andriol and 25 mg Oxandrolone results in a good gain in strength and, in steroid novices, also in muscle mass without excessive water retention and without a significant influence on testosterone production. As for the dos-age of Oxandrolone, 8-12 tablets in men and 5-6 tablets in women seem to bring the best results. The rule of thumb to take 0.125 mg/pound of body weight daily has proven successful in clinical tests. The tablets are normally taken two to three times daily after meals thus assuring an optimal absorption of the substance. Those who get the already discussed gastrointestinal pain when taking Oxandrolone are better off taking the tablets one to two hours after a meal or switching to another compound.
Since Oxandrolone is only slightly toxic and usually shows few side effects it is used by several athletes over a prolonged period of time. However Oxandrolone should not be taken for several consecutive months, since, as with almost all oral steroids it is 1 7-alpha alkylated and thus liver toxic. Oxandrolone is an all-purpose remedy which, depending on the athlete’s goal, is very versatile. Women who react sensitively to the intake of anabolic steroids achieve good results when combining Oxandrolone/Primobolan Tabs and/or Clenbuterol, without suffering from the usual virilization symptoms. Women, however, should not take more than 6 tablets daily. Otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.
Probably the largest disadvantages that come along with Oxandrolone are its high price and poor availability on the black market. Original Oxandrolone costs about $1 – 2 per tablet on the black market and is rarely available, if at all.
Newbies Research Guide reference
Oxandrolone is very low in androgen and it’s primarily used in conjunction with other steroids. This is a very safe anabolic steroid that promote protein anabolism. This drug is very popular amongst the women’s bodybuilding circuit as well as the women’s fitness circuit. This steroid is very mild and is non-andro- genic. This means it will literally not aromatize under most normal conditions (much like primabolon). This drug is most commonly know for its ability of promot- ing a lean and hard look; unlike most steroids that aromatize easily and create a smooth bloated look, anavar will not. Anavar does not suppress testosterone production so its good for tapering and you will not have to use HCG or Clomid after a cycle. People usually use this drug in a cutting cycle.
Dose 20-80 mg per day for men and 10-20 mg for women.
Wlliam Llewellyn (2011) – Anabolics
L. Rea (2002) – Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide